𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Structure, regulation and function of PKB/AKT—a major therapeutic target

✍ Scribed by Masahito Hanada; Jianhua Feng; Brian A Hemmings

Publisher
Elsevier Science
Year
2004
Tongue
English
Weight
524 KB
Volume
1697
Category
Article
ISSN
1570-9639

No coin nor oath required. For personal study only.

✦ Synopsis

Protein phosphorylation and dephosphorylation play a major role in intracellular signal transduction activated by extracellular stimuli. Protein kinase B (PKB/Akt) is a central player in the signal transduction pathways activated in response to growth factors or insulin and is thought to contribute to several cellular functions including nutrient metabolism, cell growth and apoptosis. Recently, several significant publications have described novel mechanisms used to regulate PKB. Since the alteration of PKB activity is associated with several human diseases, including cancer and diabetes, understanding PKB regulation is an important task if we are to develop successful therapeutics.

📜 SIMILAR VOLUMES

Structure and Functional Organization of
Structure and Functional Organization of Benthic Invertebrates in a Regulated Stream
✍ Tadeusz Fleituch 📂 Article 📅 2003 🏛 John Wiley and Sons 🌐 English ⚖ 222 KB

## Abstract This paper examines modifications of benthic structure and species/traits organization of macroinvertebrate communities affected by various hydro‐technical structures in the regulated mountain Trzemesnia stream (southern Poland). The samples of aquatic invertebrates were collected seaso

Protein targeting to subnuclear higher o
Protein targeting to subnuclear higher order structures: A new level of regulation and coordination of nuclear processes
✍ M. Cristina Cardoso; Heinrich Leonhardt 📂 Article 📅 1998 🏛 John Wiley and Sons 🌐 English ⚖ 215 KB

Though there are no separating membranes within the nucleus, different factors are often concentrated at sites where their respective function is required, a phenomenum referred to as functional organization of the nucleus. How is then this organization achieved and how are the different metabolic p