✦ LIBER ✦

Structure-reactivity probes for active site shapes of cholesterol esterase by carbamate inhibitors

✍ Scribed by Gialih Lin; Chuen-Tzwu Shieh; Yi-Chin Tsai; Ching-Ing Hwang; Chun-Ping Lu; Gan-Hong Chen

Book ID: 114149941
Publisher: Elsevier Science
Year: 1999
Tongue: English
Weight: 456 KB
Volume: 1431
Category: Article
ISSN: 0167-4838
DOI: 10.1016/s0167-4838(99)00073-4

No coin nor oath required. For personal study only.

📜 SIMILAR VOLUMES

Molecular Recognition by Cholesterol Est

Molecular Recognition by Cholesterol Esterase of Active Site Ligands: Structure−Reactivity Effects for Inhibition by Aryl Carbamates and Subsequent Carbamylenzyme Turnover †

✍ Feaster, Shawn R.; Lee, Keun; Baker, Nathan; Hui, David Y.; Quinn, Daniel M. 📂 Article 📅 1996 🏛 American Chemical Society 🌐 English ⚖ 748 KB

Structure−Reactivity Relationships for t

Structure−Reactivity Relationships for the Inhibition Mechanism at the Second Alkyl-Chain-Binding Site of Cholesterol Esterase and Lipase †

✍ Lin, Gialih; Shieh, Chuen-Tzwu; Ho, Hong-Chi; Chouhwang, Ju-Yueh; Lin, Wen-Yuan; 📂 Article 📅 1999 🏛 American Chemical Society 🌐 English ⚖ 127 KB

Probing the Active Sites of Butyrylcholi

Probing the Active Sites of Butyrylcholinesterase and Cholesterol Esterase with Isomalathion: Conserved Stereoselective Inactivation of Serine Hydrolases Structurally Related to Acetylcholinesterase

✍ Doorn, Jonathan A.; Talley, Todd T.; Thompson, Charles M.; Richardson, Rudy J. 📂 Article 📅 2001 🏛 American Chemical Society 🌐 English ⚖ 159 KB

Probing conformations of the glycerol ba

Probing conformations of the glycerol backbones of triacyglycerols in the active site of lipase by 1,2-cyclopentane-carbamates: The meso effect for the enzyme inhibition

✍ Gialih Lin; Fu-Hwey Lai; Bo-I Tsai; Chi-Wei Hsieh; Hou-Jen Tsai 📂 Article 📅 2006 🏛 Elsevier Science 🌐 English ⚖ 381 KB

Probing the peripheral anionic site of a

Probing the peripheral anionic site of acetylcholinesterase with quantitative structure activity relationships for inhibition by biphenyl-4-acyoxylate-4′-N-Butylcarbamates

✍ Gialih Lin; Gan-Hong Chen; Shih-Chieh Yeh; Chun-Ping Lu 📂 Article 📅 2005 🏛 John Wiley and Sons 🌐 English ⚖ 294 KB 👁 1 views

## Abstract Biphenyl‐4‐acyoxylate‐4′‐__N__‐butylcarbamates 1–8 are synthesized from 4,4′‐biphenol and are characterized as the pseudosubstrate inhibitors of acetylcholinesterase. In other words, the inhibitors bind to the enzyme and react with the enzyme to form the tetrahedral intermediates for th

Active-Site Disruption in NativeLimulusH

Active-Site Disruption in NativeLimulusHemocyanin and Its Subunits by Disulfide-Bond Reductants: A Chemical Probe for the Study of Structure–Function Relationships in the Hemocyanins

✍ Richard Topham; Shirley Tesh; Gregory Cole; Danielle Mercatante; Amy Westcott; C 📂 Article 📅 1998 🏛 Elsevier Science 🌐 English ⚖ 447 KB