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Structure of the ROC domain from the Parkinson's disease-associated leucine-rich repeat kinase 2 reveals a dimeric GTPase

✍ Scribed by Deng, J.; Lewis, P. A.; Greggio, E.; Sluch, E.; Beilina, A.; Cookson, M. R.


Book ID
115499926
Publisher
National Academy of Sciences
Year
2008
Tongue
English
Weight
944 KB
Volume
105
Category
Article
ISSN
0027-8424

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Leucine-rich repeat kinase 2 (LRRK2): A
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## Abstract Parkinson's disease (PD) is the most common neurodegenerative movement disorder, with a prevalence of more than 1% after the age of 65 years. Mutations in the gene encoding leucine‐rich repeat kinase‐2 (__LRRK2__) have recently been linked to autosomal dominant, late‐onset PD that is cl