Structure of the Mouse 92-kDa Type IV Collagenase Gene : In Vitro and in Vivo Expression in Transient Transfection Studies and Transgenic Mice
โ Scribed by C. MUNAUT; P. REPONEN; P. HUHTAL; S. KONTUSAARI; J.-M. FOIDART; K. TRYGGVASON
- Book ID
- 119870236
- Publisher
- John Wiley and Sons
- Year
- 1994
- Tongue
- English
- Weight
- 178 KB
- Volume
- 732
- Category
- Article
- ISSN
- 0890-6564
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The malignant dissemination of tumors has been shown to require expression of one or more members of the matrix metalloprotease (MMP) enzyme family, whose function is to catalyze degradation of extracellular matrix proteins. In human squamous cell carcinoma (SCC) of the skin, expression of the MMP 9
We have previously shown that transforming growth factor-ฮฒ1 (TGFฮฒ1) mRNA is consistently overexpressed in squamous cell carcinomas relative to normal mouse skin. Here we show that 92-kDa type IV collagenase (matrix metalloproteinase) (MMP-9) mRNA was likewise progressively overexpressed during mouse