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Structure of the insulin receptor ectodomain reveals a folded-over conformation

โœ Scribed by McKern, Neil M.; Lawrence, Michael C.; Streltsov, Victor A.; Lou, Mei-Zhen; Adams, Timothy E.; Lovrecz, George O.; Elleman, Thomas C.; Richards, Kim M.; Bentley, John D.; Pilling, Patricia A.


Book ID
109896142
Publisher
Nature Publishing Group
Year
2006
Tongue
English
Weight
233 KB
Volume
443
Category
Article
ISSN
0028-0836

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The insulin receptor is an integral transmembrane glycoprotein comprised of two alpha-(approximately 135 kDa) and two beta-(approximately 95 kDa) subunits, which is synthesized as a single polypeptide chain precursor (alpha beta). The primary sequence of the human insulin receptor (hIR) protein, ded