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Structure of the Human MSH2 Locus and Analysis of Two Muir-Torre Kindreds for msh2 Mutations

✍ Scribed by Richard D. Kolodner; Nigel R. Hall; James Lipford; Michael F. Kane; M.R.S. Rao; Paul Morrison; Lori Wirth; Paul J. Finan; John Burn; Pamela Chapman; Christene Earabino; Elizabeth Merchant; D.Timothy Bishop


Book ID
115612507
Publisher
Elsevier Science
Year
1994
Tongue
English
Weight
918 KB
Volume
24
Category
Article
ISSN
0888-7543

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## Communicated by Garry R. Cutting A substantial proportion of MLH1 and MSH2 gene mutations in hereditary nonpolyposis colon cancer syndrome (HNPCC) families are characterized by nucleotide substitutions, either within the coding sequence (missense or silent mutations) or in introns. The question