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Structure of the human filamin A actin-binding domain

✍ Scribed by Ruskamo, Salla ;Ylänne, Jari

Book ID
104478500
Publisher
International Union of Crystallography
Year
2009
Tongue
English
Weight
698 KB
Volume
65
Category
Article
ISSN
0907-4449

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✦ Synopsis

Filamin A (FLNa) is a large dimeric protein that binds to actin filaments via its actin-binding domain (ABD). The crystal structure of this domain was solved at 3.2 A resolution. The domain adopts a closed conformation typical of other ABDs, but also forms a dimer both in crystallization conditions and in solution. The structure shows the localization of the residues mutated in patients with periventricular nodular heterotopia or otopalatodigital syndrome. Structural analysis predicts that mutations in both types of disorder may affect actin binding.

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