✦ LIBER ✦

Structure of the HLA class I region and expression of its resident genes

✍ Scribed by Daniel E. Geraghty

Publisher: Elsevier Science
Year: 1993
Tongue: English
Weight: 692 KB
Volume: 5
Category: Article
ISSN: 0952-7915
DOI: 10.1016/0952-7915(93)90073-2

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✦ Synopsis

The past year has seen several advances in the analysis of the HLA class I region and some of its resident genes. A description of the human class I gene family and the cloning of the class I region in yeast artificial chromosomes have provided two steps forward in the analysis of the class I region. Advances have been made in understanding the expression of the non-classical HLA class lb genes and work with the murine class lb proteins has demonstrated that these antigens can present a specialized subset of peptides to the immune system.

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