Structure of swinholide A, a potent cytotoxic macrolide from the Okinawan marine sponge Theonella Swinhoei
โ Scribed by Motomasa Kobayashi; Jun-ichi Tanaka; Taketo Katori; Miki Matsuura; Isao Kitagawa
- Publisher
- Elsevier Science
- Year
- 1989
- Tongue
- French
- Weight
- 270 KB
- Volume
- 30
- Category
- Article
- ISSN
- 0040-4039
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Pre-swmhohde A (la), the monomenc carboxyhL &id of swmholidc A (2) hdb been mIdI& from a sponge collected m Papua New Gumea Its stereochemIstry matches the absolute chlrahty recently establrshed for 2 In 1988 Bergqulst' pubhshed descnptlons of 2.5 common shallow water spongef from Montupore Island a
Theonellapeptolide-Id (TNLP), a cyclic tridecapeptide lactone, was crystallized from dimethylformamide-water solution. In the asymmetric unit, two peptide molecules were combined with solvent molecules, and the total molecular weight was over 3000 Dalton. The crystal structure including solvent mole