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Structure of PAK1 in an Autoinhibited Conformation Reveals a Multistage Activation Switch

✍ Scribed by Ming Lei; Wange Lu; Wuyi Meng; Maria-Carla Parrini; Michael J Eck; Bruce J Mayer; Stephen C Harrison


Book ID
117266972
Publisher
Elsevier Science
Year
2000
Tongue
English
Weight
480 KB
Volume
102
Category
Article
ISSN
0092-8674

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We describe the solution ('H-nmr) and calculated conformations of the opiatelike peptide dermorphin and the analysis of structure-conformation-activity relationships in the series [Alan]dermorphin. We used 'H-nmr spectroscopy to study dermorphin and its analogs [Alan]dermorphin (with n = 1, 2...7) d