Structure of ophiorines A and B; novel type gluco indole alkaloids isolated from ophiorrhiza spp.
✍ Scribed by Norio Aimi; Tadashi Tsuyuki; Hiroshi Murakami; Shin-ichiro Sakai; Joju Haginiwa
- Publisher
- Elsevier Science
- Year
- 1985
- Tongue
- French
- Weight
- 233 KB
- Volume
- 26
- Category
- Article
- ISSN
- 0040-4039
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✦ Synopsis
Two novel type gluco indole alkaloids, ophiorines A and B, were found in Rubiaceous plants, Ophiorrhiza japonica Bl. and 0. kuroiwai Mak., and their structures were elucidated by chemical and spectroscopical methods. In 1967, Fujita et al. 1) reported the isolation of harman from Ophiorrhiza japonica Bl. We were interested in a closer investigation of the constituents of this plant, since recently pharmacologically active alkaloids were isolated from the same genus. 2) The extract of the leaves of o. japonica was partitioned between chloroform and water. From the water layer two novel betaine type indole alkaloids, ophiorines A (,&I and B (g), were3fsolated. The same alkaloids, accompanied