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Structure of N-[4-hydroxy-3,5-bis(1-pyrrolidinylmethyl)phenyl]-N'-(4-methoxyphenyl)urea

✍ Scribed by Główka, M. L. ;Codding, P. W.


Book ID
114507925
Publisher
International Union of Crystallography
Year
1991
Tongue
English
Weight
355 KB
Volume
47
Category
Article
ISSN
0108-2701

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The Synthesis of 3-[3-(4-chlorophenyl)-1
✍ William V. Murray 📂 Article 📅 1993 🏛 Elsevier Science 🌐 French ⚖ 203 KB

Compound 2 was synthesized in 4 steps in 65% overall yield. Mechanistic studies of the key pyrazole forming step revealed a tetrahyrofuran intermediate (10) of the starting l-(4-chlorophenyl)-6-hydroxyhexane-1,8dione (3). This intermediate reverses the normal regioselectivity observed in additions