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Structure of interleukin 16 resembles a PDZ domain with an occluded peptide binding site

✍ Scribed by Mühlhahn, Peter ;Zweckstetter, Markus ;Georgescu, Julia ;Ciosto, Cornelia ;Renner, Christian ;Lanzendörfer, Martin ;Lang, Kurt ;Ambrosius, Dorothee ;Baier, Michael ;Kurth, Reinhard ;Holak, Tad A.


Book ID
109514477
Publisher
Nature Publishing Group
Year
1998
Tongue
English
Weight
826 KB
Volume
5
Category
Article
ISSN
1545-9993

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## Abstract Using X‐ray crystallography, a human monoclonal IgM cryoglobulin (Mez) was found to have an unusual combining site topography. Analysis of the unliganded Fv at 2.6 Å resolution revealed that the HCDR3 had partitioned the active site into two compartments [Ramsland PA __et al.__ 2000. __