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Structure of ( E )-4-Hydroxy-3-methyl-but-2-enyl Diphosphate Reductase, the Terminal Enzyme of the Non-Mevalonate Pathway

✍ Scribed by Rekittke, Ingo; Wiesner, Jochen; Röhrich, Rene; Demmer, Ulrike; Warkentin, Eberhard; Xu, Weiya; Troschke, Kathrin; Hintz, Martin; No, Joo Hwan; Duin, Evert C.; Oldfield, Eric; Jomaa, Hassan; Ermler, Ulrich


Book ID
127271652
Publisher
American Chemical Society
Year
2008
Tongue
English
Weight
763 KB
Volume
130
Category
Article
ISSN
0002-7863

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✍ Stefan Hecht; Sabine Amslinger; Johann Jauch; Klaus Kis; Viola Trentinaglia; Pet 📂 Article 📅 2002 🏛 Elsevier Science 🌐 French ⚖ 96 KB

Hydroxy-2-methylbut-2-enyl 4-diphosphate (6) has been recently detected as an intermediate of isoprenoid biosynthesis via 1-deoxy-D-xylulose 5-phosphate. The compound was synthesized in two steps from 2-methyl-2-vinyloxirane with an overall yield of 72%. We also report a method affording [1-3 H]-6 a