𝔖 Bobbio Scriptorium
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Structure of conformationally constrained peptides: From model compounds to bioactive peptides

✍ Scribed by C. Toniolo

Book ID
102762416
Publisher
Wiley (John Wiley & Sons)
Year
1989
Tongue
English
Weight
541 KB
Volume
28
Category
Article
ISSN
0006-3525

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✦ Synopsis

The use of backbone conformational constraints has acquired increasing importance in the design and synthesis of structurally restricted agonists and antagonists of bioactive peptides.

Here I discuss the preferred conformations of four among the most popular types of such peptide surrogates: (a) Peptides from Ca~a-dialkylated residues, (b) tetrazolyl peptides, (c) ( y -and 6-) lactam-containing peptides, and (d) thiated peptides. Emphasis i s given to conformational energy computations and x-ray diffraction analyses of selected model compounds and analogues of small bioactive peptides such L U the formylmethionyl tripeptide chemoattractant and MIF.

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