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Structure of complex of synthetic HIV-1 protease with a substrate-based inhibitor at 2.3 A resolution

✍ Scribed by Miller, M; Schneider, J; Sathyanarayana, B.; Toth, M.; Marshall, G.; Clawson, L; Selk, L; Kent, S.; Wlodawer, A


Book ID
118199367
Publisher
American Association for the Advancement of Science
Year
1989
Tongue
English
Weight
944 KB
Volume
246
Category
Article
ISSN
0036-8075

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HIV-1 Protease Specificity Derived from
✍ D.B. Kassel; M.D. Green; R.S. Wehbie; R. Swanstrom; J. Berman πŸ“‚ Article πŸ“… 1995 πŸ› Elsevier Science 🌐 English βš– 670 KB

A rapid and semiquantitative method is described for determining the relative \(k_{\mathrm{ca}} / K_{m}\) for individual peptides in defined substrate mixtures. The method utilizes electrospray ionization/mass spectrometry alone to semiquantitatively determine relative peptide substrate turnover rat