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Structure of amphotericin B aggregates as revealed by UV and CD spectroscopies

✍ Scribed by C. Ernst; J. Grange; H. Rinnert; G. Dupont; J. Lematre

Publisher: Wiley (John Wiley & Sons)
Year: 1981
Tongue: English
Weight: 626 KB
Volume: 20
Category: Article
ISSN: 0006-3525
DOI: 10.1002/bip.1981.360200802

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✦ Synopsis

Abstract

The aqueous and hydroalcoholic solutions of the heptenic macrolide amphotericin B display strong and variable signals in CD and absorption spectroscopies in the range of the π* ← π transition. An interpretation of the spectroscopic changes is proposed based on the equilibrium between two forms of the intermolecular organization: the aggregated one (A) with strong excitonic interaction and the nonaggregative one (B) whose spectra are like those of linear conjugated polyenes in true solution with a well‐developed vibrational structure. The intermediate spectra are fitted by linear combination of the A‐ and B‐form spectra. A two‐level organization of the aggregates is proposed for the A‐form: (1) a close packing of few molecules, which is the origin of the absorption maxima hypsochromic shift; and (2) interaction between the preceding small units inside the aggregates, which is spectroscopically expressed by the intense CD couplet.

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