Two molecular dynamics simulations were performed for a modeled complex of mouse acetylcholinesterase liganded with huperzine A (HupA). Analysis of these simulations shows that HupA shifts in the active site toward Tyr 337 and Phe 338, and that several residues in the active site area reach out to m
✦ LIBER ✦
Structure of acetylcholinesterase complexed with the nootropic alkaloid, (–)-huperzine A
✍ Scribed by Raves, Mia L. ;Harel, Michal ;Pang, Yuan-Ping ;Silman, Israel ;Kozikowski, Alan P. ;Sussman, Joel L.
- Book ID
- 109964497
- Publisher
- Nature Publishing Group
- Year
- 1997
- Tongue
- English
- Weight
- 825 KB
- Volume
- 4
- Category
- Article
- ISSN
- 1545-9993
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