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Structure of a key intermediate in the asymmetric synthesis of (+)-KDO

โœ Scribed by Lynch, V. M. ;Zinke, P. W. ;Martin, S. F. ;Davis, B. E.


Book ID
114507979
Publisher
International Union of Crystallography
Year
1991
Tongue
English
Weight
301 KB
Volume
47
Category
Article
ISSN
0108-2701

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An efficient asymmetric synthesis of key
โœ Stephen K. Taylor; Milica Ivanovic; Lloyd J. Simons; Matthew M. Davis ๐Ÿ“‚ Article ๐Ÿ“… 2003 ๐Ÿ› Elsevier Science ๐ŸŒ English โš– 190 KB

Efficient, formal syntheses of aphanorphine and eptazocine are reported that involve epoxide cyclizations. The necessary chiral epoxides were prepared following treatment of diols prepared by Sharpless asymmetric osmylations of an alkene. The cyclizations formed a ring compound with the same enantio