𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Structure investigation of Maltacine C1a, C1b, C2a and C2b—cyclic peptide lactones of the Maltacine complex from Bacillus subtilis

✍ Scribed by Gunnar Hagelin

Publisher
John Wiley and Sons
Year
2005
Tongue
English
Weight
251 KB
Volume
40
Category
Article
ISSN
1076-5174

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

A new complex of cyclic peptide lactone antibiotics from Bacillus subtilis, which we named Maltacines, has recently been described. The structure elucidation of four of them is reported in this paper. The amino acid sequences and structures of the peptides were found by MS^n^ of the ring‐opened linear peptides, which gave uninterrupted sequences of Bn and Y″n ions. The identities of three unknown residues in the sequences were solved by a combination of derivatisation with phenylisothiocyanate (PITC), high‐resolution mass spectrometry and H/D exchange. The nature and position of the cyclic structure was disclosed by a chemo‐selective ring opening with Na^18^OH and was found to be a lactone formed between a hydroxyl of residue number 4 and the C‐terminal amino acid number 12. For verification of the structure of the B2^+^ ion, peptides with different combinations of P/Q and P/K at the N‐terminus were synthesised. The structure of the four peptides were found to be: C1a and C2a: cyclo‐4,12(P‐Q‐Y‐Adip‐V‐E‐T‐Y‐Orn‐103‐Y‐I‐OH) and C1b/C2b: cyclo‐4,12(P‐Q‐Y‐Adip‐V‐E‐T‐Y‐K‐103‐Y‐I‐OH). Adip = aminodihydroxy pentanoic acid. Copyright © 2005 John Wiley & Sons, Ltd.

📜 SIMILAR VOLUMES

Structure investigation of Maltacine D1a
Structure investigation of Maltacine D1a, D1b and D1c—cyclic peptide lactones of the Maltacine complex from Bacillus subtilis
✍ Gunnar Hagelin 📂 Article 📅 2005 🏛 John Wiley and Sons 🌐 English ⚖ 286 KB

## Abstract A new complex of cyclic peptide lactone antibiotics from __Bacillus subtilis__, which we named __Maltacines__ has recently been described. The structure elucidation of three of them is reported in this paper. The amino acid sequences and structures of the peptides were found by MS^__n__

Structure investigation of maltacine B1a
Structure investigation of maltacine B1a, B1b, B2a and B2b: cyclic peptide lactones of the maltacine complex from Bacillus subtilis
✍ Gunnar Hagelin 📂 Article 📅 2005 🏛 John Wiley and Sons 🌐 English ⚖ 279 KB

## Abstract A new complex of cyclic peptide lactone antibiotics from __Bacillus subtilis__, which we named maltacines, has recently been described. The structure elucidation of four of them is reported in this paper. The amino acid sequences and structures of the peptides were found by MS^__n__^ of

Cage opening of 1,2-(CH2OH)2-closo-1,2-C
Cage opening of 1,2-(CH2OH)2-closo-1,2-C2B10H10 with 2-(aminomethyl)-pyridine: synthesis and structure of a cobalt salt of functionalized nido-C2B9H10 mono anion
✍ Aderemi R. Oki; Blanca Gilbes; Faina Tarasyuk; Thomas J. Emge 📂 Article 📅 2003 🏛 John Wiley and Sons 🌐 English ⚖ 338 KB 👁 1 views

## Abstract The reaction of 1,2‐(CH~2~OH)~2~‐__closo__‐1,2‐C~2~B~10~ H~10~ carborane with 2‐(aminomethyl)‐pyridine in methylene chloride at room temperature led to the partial cage degradation of the __closo__ carborane and its conversion to the __nido__ derivative. The addition of cobalt chloride