## Abstract Secreted frizzled‐related proteins (sFRPs) are glycoproteins that are recognized as Wnt antagonists. To identify the functional domains that are involved in Wnt antagonist function, several sFRP‐1 mutants and sFRP‐1/sFRP‐2 chimeras were generated. These mutants were characterized in an
✦ LIBER ✦
Structure-function analysis of Frizzleds
✍ Scribed by Hsien-yu Wang; Tong Liu; Craig C. Malbon
- Book ID
- 113527921
- Publisher
- Elsevier Science
- Year
- 2006
- Tongue
- English
- Weight
- 219 KB
- Volume
- 18
- Category
- Article
- ISSN
- 0898-6568
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## Abstract Preclinical pharmacology studies conducted with experimental medicines currently focus on assessments of drug effects attributed to a drug's putative mechanism of action. The high failure rate of medicines in clinical trials, however, underscores that the information gathered from these