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Structure elucidation of the thermal degradation products of the nucleotide cofactors NADH and NADPH by nano-ESI-FTICR-MS and HPLC-MS

✍ Scribed by Diana Hofmann; Astrid Wirtz; Beatrix Santiago-Schübel; Ulrich Disko; Martina Pohl


Book ID
105893617
Publisher
Springer
Year
2010
Tongue
English
Weight
249 KB
Volume
398
Category
Article
ISSN
1618-2650

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✍ Wessels, Peter ;Ogorka, Jörg ;Schwinger, Gerhard ;Ulmer, Martin 📂 Article 📅 1993 🏛 John Wiley and Sons 🌐 English ⚖ 451 KB

## Abstract Degradation products obtained under severe alkaline stress of the drug substance ENA 713, a compound developed for the treatment of DAT (dementia of the __Alzheimer__ type), have been identified by on‐line coupled reversed phase HPLC‐GC‐MS as 3‐hydroxyaceto‐phenone and 3‐hydroxystyrene.