Structure elucidation of metabolites of swertiamarin produced by Aspergillus niger

✍ Scribed by Chang Jun; Zhao Xue-Ming; Liu Chang-Xiao; Zhang Tie-Jun

• Book ID: 103838042
• Publisher: Elsevier Science
• Year: 2008
• Tongue: English
• Weight: 127 KB
• Volume: 878
• Category: Article
• ISSN: 0022-2860
• DOI: 10.1016/j.molstruc.2007.07.031

✦ Synopsis

The in vitro metabolism of swertiamarin was carried out in preparative scale using the fungus Aspergillus niger and the metabolites were isolated by semi-preparative HPLC combined with liquid-liquid extraction. Two metabolites, erythrocentaurin and one new compound were obtained and identified by 1 H, 13 C and 2D NMR and high resolution MS. The anti-inflammatory activity of the novel metabolite was tested and compared with that of swertiamarin in a mice model.