Structure determination of polysaccharides in Aloe saponaria (Hill.) Haw. (Liliaceae)
✍ Scribed by Akira Yagi; Kozo Hamada; Itsuo Nishioka; Kunihide Mihashi; Nobuo Harada
- Publisher
- John Wiley and Sons
- Year
- 1984
- Tongue
- English
- Weight
- 544 KB
- Volume
- 73
- Category
- Article
- ISSN
- 0022-3549
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✦ Synopsis
ume of distribution of drugs during constant-rate intravenous infusion. This technique is based on the initiaI slope of the plasma drug concentration uersus time profile during infusion. The resulting estimate of the apparent volume of distribution should prove useful as an initial estimate of this pharmacokinetic parameter, especially for investigational drugs for which no pharmacokinetic parameter estimates are available, until additional data permit estimation of the appropriate volume term by conventional methods (14). In addition, this estimate of the apparent volume of distribution can be used with two intrainfusion concentration uersus time points as input to the Chiou-Hsu equation (5-7), from which total body clearance for individual patients can be calculated. In illustrating the theoretical principles and potential errors involved in the initial slope technique, equations were derived and plots presented of dimensionless concentration uersus dimensionless time. To our knowledge such an approach, although widely used in engineering, has not been used previously in pharmacokinetics.
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