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Structure determination of aligned samples of membrane proteins by NMR spectroscopy

✍ Scribed by Alexander A. Nevzorov; Michael F. Mesleh; Stanley J. Opella

Publisher
John Wiley and Sons
Year
2004
Tongue
English
Weight
439 KB
Volume
42
Category
Article
ISSN
0749-1581

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✦ Synopsis

Abstract

The paper briefly reviews the process of determining the structures of membrane proteins by NMR spectroscopy of aligned samples, describes the integration of recent developments in the interpretation of spectra of aligned proteins and illustrates the application of these methods to the trans‐membrane helical domain of a protein. The emerging methods of interpreting the spectral parameters from aligned samples of isotopically labeled proteins provide opportunities for simultaneously assigning the spectra and determining the structures of the proteins, and also for comparing the results from solid‐state NMR experiments on completely aligned samples with those of solution NMR experiments on weakly aligned samples. Copyright © 2004 John Wiley & Sons, Ltd.

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