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Structure determination and synthesis of lysine isopeptides influencing on cell proliferation

✍ Scribed by Gy. Szókán; M. Almás; K. Krizsán; A. R. Khlafulla; E. Tyihák; B. Szende

Publisher
Wiley (John Wiley & Sons)
Year
1997
Tongue
English
Weight
180 KB
Volume
42
Category
Article
ISSN
0006-3525

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✦ Synopsis

The clavicepamines are lysine-rich basic proteins isolated from saprophytic culture of ergot (Claviceps purpurea), having human pharmacological importance.

Based on structure determinations, it was demonstrated that the 1-lysine (poly)peptides are the fundamental structural units of clavicepamines.

To study the relationship between chemical structure and biological effect, solution and solid-phase synthesis of lysine isopeptides were performed. Poly-1-lysines were synthesized with polycondensation via application of p-nitrophenylester temporarily protecting groups together with simultaneous activation. The biological investigations of poly-1-lysines showed a cell-proliferation retarding effect, so they inhibit growth of some animal tumors, practically without toxic side effects.

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