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Structure-dependent metallokinetics of antidiabetic vanadyl-picolinate complexes in rats: studies on solution structure, insulinomimetic activity, and metallokinetics

✍ Scribed by Hiroyuki Yasui; Asuka Tamura; Toshikazu Takino; Hiromu Sakurai

Book ID: 108403712
Publisher: Elsevier Science
Year: 2002
Tongue: English
Weight: 614 KB
Volume: 91
Category: Article
ISSN: 0162-0134
DOI: 10.1016/s0162-0134(02)00443-9

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✍ Hiromu Sakurai; Hiroyuki Yasui 📂 Article 📅 2003 🏛 John Wiley and Sons 🌐 English ⚖ 154 KB

In view of the clinical use of vanadium compounds, we prepared seven analogs of a vanadylÀpicolinate complex (VO(pic) 2 ) with VO(N 2 O 2 ) coordination mode, which was found in 1995 to exhibit highly effective and long-term insulinomimetic activity in treating both streptozotocin (STZ)-induced type