Structure comparison and evolutionary relations between elongation factors EF-Tu (EF-1α) and SUP 2 proteins

✍ Scribed by M. G. Samsonova; S. G. Inge-Vechtomov; P. Taylor

• Book ID: 104624546
• Publisher: Springer Netherlands
• Year: 1991
• Tongue: English
• Weight: 827 KB
• Volume: 85
• Category: Article
• ISSN: 0016-6707
• DOI: 10.1007/bf00056104

✦ Synopsis

On the basis of high homology and structural similarity, three genes, SUP2 Saccharomyces cerevisiae, SUP2 Pich& pinus and GST 1 Homo sapiens, might be considered as members of one family named SUP2. Comparison of the primary structure of SUP2 proteins and elongation factors EF-Tu(EF-la) from 19 different species was performed. It was found that SUP2 proteins bear more homology to eukaryotic elongation factor than to procaryotic EF-Tu, though the degree of sequence conservation in SUP2 proteins is smaller than in EF-la factors. The extensive phylogenetic analysis of SUP2 and EF-Tu(EF-1 a) genes was performed by means of 3 methods, 2 phenetic and one cladystic (maximal parsimony). The data support the close relation of SUP2 genes to other elongation factor genes.

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nucleotide sequences are taken from the original articles ** -gene does not have any designation