𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Structure-based optimization of morpholino-triazines as PI3K and mTOR inhibitors

✍ Scribed by Anders Poulsen; Meredith Williams; Harish Mysore Nagaraj; Anthony D. William; Haishan Wang; Chang Kai Soh; Zheng Chang Xiong; Brian Dymock


Book ID
113496457
Publisher
Elsevier Science
Year
2012
Tongue
English
Weight
781 KB
Volume
22
Category
Article
ISSN
0960-894X

No coin nor oath required. For personal study only.


πŸ“œ SIMILAR VOLUMES


Structure-based optimization of pyrazolo
✍ Steven T. Staben; Timothy P. Heffron; Daniel P. Sutherlin; Seema R. Bhat; George πŸ“‚ Article πŸ“… 2010 πŸ› Elsevier Science 🌐 English βš– 1007 KB

## a b s t r a c t Starting from HTS hit 1a, X-ray co-crystallization and molecular modeling were used to design potent and selective inhibitors of PI3-kinase. Bioavailablity in this series was improved through careful modulation of physicochemical properties. Compound 12 displayed in vivo knockdo