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Structure Based Model for the Prediction of Phospholipidosis Induction Potential of Small Molecules

โœ Scribed by Sun, Hongmao; Shahane, Sampada; Xia, Menghang; Austin, Christopher P.; Huang, Ruili


Book ID
120474017
Publisher
American Chemical Society
Year
2012
Tongue
English
Weight
465 KB
Volume
52
Category
Article
ISSN
0095-2338

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The potential for various small molecule organic crystals to undergo complete mechanically induced disordering is investigated. A model is proposed, which considers changes in free energy required for lattice incorporation of a critical dislocation density. Application requires knowledge of a few ph