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Structure-based drug design: From nucleic acid to membrane protein targets

✍ Scribed by Magdalena M. Dailey; Chayanendu Hait; Patrick A. Holt; Jon M. Maguire; Jason B. Meier; M. Clarke Miller; Luigi Petraccone; John O. Trent

Book ID
113956617
Publisher
Elsevier Science
Year
2009
Tongue
English
Weight
902 KB
Volume
86
Category
Article
ISSN
0014-4800

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A convenient small scale synthesis has been developed for obtaining peptide nucleic acid oligomers (PNAs). PNAs have been conjugated to a protein, staphylococcal nuclease, through disulfide exchange between a cysteine at the 3'-(carboxy) end of the PNA and an introduced cysteine on the surface of th