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Structure-Based Design of Inhibitors of the Aspartic Protease Endothiapepsin by Exploiting Dynamic Combinatorial Chemistry

✍ Scribed by Mondal, Milon; Radeva, Nedyalka; Köster, Helene; Park, Ahyoung; Potamitis, Constantinos; Zervou, Maria; Klebe, Gerhard; Hirsch, Anna K. H.


Book ID
121711838
Publisher
John Wiley and Sons
Year
2014
Tongue
English
Weight
752 KB
Volume
53
Category
Article
ISSN
0044-8249

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## Abstract A series of novel nonpeptide inhibitors of the pp60^c‐Src^ (Src) SH2 domain is described that exploit multifunctional group replacement of the phenylphosphate moiety of phosphotyrosine (pTyr). Relative to an x‐ray structure of citrate complexed to the pTyr binding site of the Src SH2 do