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Structure-based design of a novel thiazolone scaffold as HCV NS5B polymerase allosteric inhibitors

✍ Scribed by Shunqi Yan; Todd Appleby; Gary Larson; Jim Z. Wu; Robert Hamatake; Zhi Hong; Nanhua Yao

Book ID
108074137
Publisher
Elsevier Science
Year
2006
Tongue
English
Weight
484 KB
Volume
16
Category
Article
ISSN
0960-894X

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Hepatitis C (HCV) belongs to the Flaviviridae family of positivesense, single-stranded RNA viruses. The HCV genome encodes a polyprotein, comprised of 3000 amino acid residues, which is processed into both structural and nonstructural proteins. [1] HCV infection is a significant global health issue;