𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Structure-based and ligand-based drug design for microsomal prostaglandin E synthase-1 inhibitors

✍ Scribed by Li, Chia-Ling; Chang, Tung-Ti; Sun, Mao-Feng; Chen, Hsin-Yi; Tsai, Fuu-Jen; Fisher, Mark; Chen, Calvin Yu-Chian; Lee, Chun-Lin; Fang, Wen-Chang; Wong, Yung-Hao


Book ID
120498618
Publisher
Taylor and Francis Group
Year
2011
Tongue
English
Weight
416 KB
Volume
37
Category
Article
ISSN
0892-7022

No coin nor oath required. For personal study only.


πŸ“œ SIMILAR VOLUMES


Thymidylate synthase inhibition: A struc
✍ M. Paola Costi πŸ“‚ Article πŸ“… 1998 πŸ› John Wiley and Sons 🌐 English βš– 432 KB πŸ‘ 2 views

Thymidylate synthase (TS) is a very interesting target in antiproliferative diseases. Its inhibition causes thimineless death of the cells and compounds inhibiting TS are widely used in anticancer therapy. The classical antifolate TS inhibitors are structural analogs of the folate cofactor; they oft

Structure-based drug design of nonpeptid
✍ Vincent J. Kalish; John H. Tatlock; Jay F. Davies II; Stephen W. Kaldor; Bruce A πŸ“‚ Article πŸ“… 1995 πŸ› Elsevier Science 🌐 English βš– 290 KB

The cocrystal structures of LY289612 and LY297135 were used as a starting point in the design of nonpeptidic HIV-1 protease inhibitors. This report details the discovery of a series of novel aromatic P2 replacement groups. The 3-hydroxy-2-methyl benzoic acid group, discovered in AG1254, was incorpor