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Structure-Based and in silico Design of Hsp90 Inhibitors

✍ Scribed by Miriam Sgobba; Giulio Rastelli

Publisher: John Wiley and Sons
Year: 2009
Tongue: English
Weight: 727 KB
Volume: 4
Category: Article
ISSN: 1860-7179
DOI: 10.1002/cmdc.200900256

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✦ Synopsis

Abstract

The molecular chaperone Hsp90 is responsible for activation and stabilization of several oncoproteins in cancer cells, and has emerged as an important target in cancer treatment because of this pivotal role. In recent years, interests have arisen around structure‐based design of small molecules aimed at inhibiting the chaperone activity of Hsp90. In this review, we illustrate the recent advances in structure‐based and in silico strategies aimed at discovering and optimizing Hsp90 inhibitors.

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