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Structure and variation of human α1–antitrypsin

✍ Scribed by Carrell, Robin W.; Jeppsson, Jan-Olof; Laurell, Carl-Bertil; Brennan, Stephen O.; Owen, Maurice C.; Vaughan, Lloyd; Boswell, D. Ross


Book ID
109727017
Publisher
Nature Publishing Group
Year
1982
Tongue
English
Weight
886 KB
Volume
298
Category
Article
ISSN
0028-0836

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Human alpha 1-antitrypsin (alpha 1-AT) is a major serine protease inhibitor in plasma, secreted as a glycoprotein with a complex type of carbohydrate at three asparagine residues. To study glycosylation of heterologous proteins in yeast, we investigated the glycosylation pattern of the human alpha 1