Structure and synthesis of WF 3681, a novel aldose reductase inhibitor

✍ Scribed by Itsuo Uchida; Yoshikuni Itoh; Takayuki Namiki; Motoaki Nishikawa; Masashi Hashimoto

• Book ID: 104218518
• Publisher: Elsevier Science
• Year: 1986
• Tongue: French
• Weight: 214 KB
• Volume: 27
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/s0040-4039(00)84436-6

✦ Synopsis

The structure of WF 3681 (L), an aldose reductase inhibitor isolated from a ChaetomeIla species, has been determined on the basis of its physical and chemical properties and confirmed by a total synthesis. WF 3681 ( 1) is a fungal metabolite with potent aldose reductaseinhibitory activity. Herein we report the structure elucidation and the