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Structure and Stability of the Potato Cysteine Protease Inhibitor Group (Cv. Elkana)

✍ Scribed by Pouvreau, Laurice; Kroef, Toos; Gruppen, Harry; van Koningsveld, Gerrit; van den Broek, Lambertus A. M.; Voragen, Alhons G. J.


Book ID
126129821
Publisher
American Chemical Society
Year
2005
Tongue
English
Weight
156 KB
Volume
53
Category
Article
ISSN
0021-8561

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The effects of the peptide inhibitor acetyl pepstatin on the structural stability of the HIV-1 protease have been measured by high sensitivity calorimetric techniques. At 25Β°C and pH 3.6, acetyl pepstatin binds to HIV-1 protease with an affinity of 1.6 Ψ‹ 10 7 M -1 and an enthalpy of 7.3 ؎ 0.5 kcal/m