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Structure and regulation of the mouse GRP78 (BiP) promoter by glucose and calcium ionophore

✍ Scribed by John B. Tillman; Patricia L. Mote; Roy L. Walford; Stephen R. Spindler


Book ID
116132675
Publisher
Elsevier Science
Year
1995
Tongue
English
Weight
535 KB
Volume
158
Category
Article
ISSN
0378-1119

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GRP78/BiP, a molecular chaperone in the endoplasmic reticulum, is induced under such adverse conditions for cell survival as glucose starvation. Induction of GRP78 has been shown to coincide with G1 cell cycle arrest, which is an important cellular defense system. In this study, we investigated invo