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Structure and Orientation of Peptide Inhibitors Bound to Beta-amyloid Fibrils

✍ Scribed by Zhongjing Chen; Gerd Krause; Bernd Reif


Book ID
116662502
Publisher
Elsevier Science
Year
2005
Tongue
English
Weight
998 KB
Volume
354
Category
Article
ISSN
0022-2836

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## Abstract Amyloid fibrils are self‐associating filamentous structures deposited in extracellular tissue in various neurodegenerative and protein misfolding disorders. It has been shown that beta‐sheet‐breaker (BSB) peptides may interfere with amyloid fibril assembly. Although BSB peptides are pro