Structure and nuclear import function of the C-terminal domain of influenza virus polymerase PB2 subunit
✍ Scribed by Tarendeau, Franck; Boudet, Julien; Guilligay, Delphine; Mas, Philippe J; Bougault, Catherine M; Boulo, Sébastien; Baudin, Florence; Ruigrok, Rob W H; Daigle, Nathalie; Ellenberg, Jan
- Book ID
- 109966678
- Publisher
- Nature Publishing Group
- Year
- 2007
- Tongue
- English
- Weight
- 352 KB
- Volume
- 14
- Category
- Article
- ISSN
- 1545-9993
- DOI
- 10.1038/nsmb1212
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The α subunit C-terminal domain (αCTD) of RNA polymerase (RNAP) is a key element in transcription activation in__Escherichia coli__, possessing determinants responsible for the interaction of RNAP with DNA and with transcription factors. Here, the crystal structure of__E. coli__αCTD (α subunit resid
## Abstract A novel mutant of the catalytic α subunit of human protein kinase CK2 (CK2α) was designed in an attempt to clarify the role of the carboxylic‐terminal segment characteristic of vertebrates, excluding fish. Starting from the sequence alignments, we constructed a phylogenetic tree of the