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Structure and Methylation-Associated Silencing of a Gene within a Homozygously Deleted Region of Human Chromosome Band 8p22

โœ Scribed by Donal MacGrogan; Alina Levy; G.Steven Bova; William B. Isaacs; Robert Bookstein


Book ID
115613277
Publisher
Elsevier Science
Year
1996
Tongue
English
Weight
376 KB
Volume
35
Category
Article
ISSN
0888-7543

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Human prostate cancers frequently show loss of heterozygosity at loci on the short arm of chromosome 8. In order t o take a step toward isolation of the putative tumor suppressor gene(s) on 8p via positional cloning, we performed high-resolution deletion mapping in 46 prostate cancers (stage B, 20 c