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## Abstract DNA polymerases are required for DNA replication and DNA repair in all of the living organisms. Different DNA polymerases are responsible different stages of DNA metabolism, and many of them are multifunctional enzymes. It was generally assumed that the different reactions are catalyzed
We have previously shown that trivalent chromium, and hexavalent chromium in the presence of one of its primary in vivo reductants, ascorbate, can bind to DNA and form interstrand crosslinks capable of obstructing replication. This effect was demonstrated in vitro by using Sequenase Version 2.0 T7 D
Inhibitors of DNA Polymerase β from Schoepfia californica. -The structure of acids (I), extracted from the title plant, are determined by spectroscopic analyses and chemical syntheses. The activity of (I) as inhibitors of DNA polymerase β is investigated.