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Structure and functions of transcriptional coactivators p300/CBP and their roles in regulation of interleukin gene expression

โœ Scribed by Yangguang Shao; Guoping Zhang; Jun Lu; Baiqu Huang

Book ID
111785178
Publisher
Springer
Year
2004
Tongue
English
Weight
584 KB
Volume
49
Category
Article
ISSN
1001-6538

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The conserved region 1 and the extreme N-terminus of adenoviral oncoprotein E1A are essential for transforming activity. They also play roles in the interaction of E1A with p300/CBP and pRb and are involved in both transactivation and repression of host gene expression. It was reported recently that