## Abstract The docking protein p130Cas (Cas) becomes tyrosine‐phosphorylated in its central substrate domain in response to extracellular stimuli such as integrin‐mediated cell adhesion, and transmits signals through interactions with various intracellular signaling molecules such as the adaptor p
Structure and function of the p130Cas-related protein family
✍ Scribed by Nojima, Yoshihisa
- Publisher
- Informa UK (Informa Healthcare)
- Year
- 1999
- Tongue
- English
- Weight
- 734 KB
- Volume
- 9
- Category
- Article
- ISSN
- 0169-1163
No coin nor oath required. For personal study only.
📜 SIMILAR VOLUMES
p105CasL (CasL) is a recently identified signaling molecule closely related to the p130Cas (Crk-associated substrate) docking protein. CasL has a single Src homology (SH) 3 domain in its N-terminal portion followed by multiple consensus motifs for binding to SH2 domains. Like original p130Cas, CasL
## Abstract Secreted frizzled‐related proteins (sFRPs) are glycoproteins that are recognized as Wnt antagonists. To identify the functional domains that are involved in Wnt antagonist function, several sFRP‐1 mutants and sFRP‐1/sFRP‐2 chimeras were generated. These mutants were characterized in an