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Structure and function of the double-strand break repair machinery

โœ Scribed by David S. Shin; Charly Chahwan; Joy L. Huffman; John A. Tainer


Book ID
116410266
Publisher
Elsevier Science
Year
2004
Tongue
English
Weight
672 KB
Volume
3
Category
Article
ISSN
1568-7864

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## Abstract Cells, which lacked the activity of the nuclease Artemis, retained approximately 10% of unrepaired double strand breaks (DSBs) at later timepoints after ionizing radiation. Ionizing radiation induced hyperphosphorylation of Artemis mainly by ATM and in ATM deficient cells to a minor ext