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Structure and function of the DNA ligases encoded by the mammalian LIG3 gene

โœ Scribed by Tomkinson, Alan E.; Sallmyr, Annahita

Book ID
123046476
Publisher
Elsevier Science
Year
2013
Tongue
English
Weight
752 KB
Volume
531
Category
Article
ISSN
0378-1119

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The DNA ligase of Escherichia coli catalyses the NAD-dependent formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in DNA. It is essential for DNA replication and repair of damaged DNA strands. We determined the nucleotide sequence of the lig gene of Escherichia coli co