𝔖 Bobbio Scriptorium
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Structure and function of programmed death (PD) molecules

✍ Scribed by A. Folkl; D. Bienzle

Book ID
116966639
Publisher
Elsevier Science
Year
2010
Tongue
English
Weight
228 KB
Volume
134
Category
Article
ISSN
0165-2427

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## Abstract Programmed cell death‐1 (PD‐1, CD279) and its widely expressed, inducible ligand, PD‐L1 (CD274), together dampen T cell activation, but whether they are essential for allograft tolerance is unknown. We show, using gene‐deficient mice and blocking mAbs in wild‐type mice, that costimulati