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Structure and Function of HIV-1 Reverse Transcriptase: Molecular Mechanisms of Polymerization and Inhibition

โœ Scribed by Stefan G. Sarafianos; Bruno Marchand; Kalyan Das; Daniel M. Himmel; Michael A. Parniak; Stephen H. Hughes; Eddy Arnold

Book ID
116663931
Publisher
Elsevier Science
Year
2009
Tongue
English
Weight
918 KB
Volume
385
Category
Article
ISSN
0022-2836

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The human immunodeficiency virus (HIV) epidemic is an important medical problem. Although combination drug regimens have produced dramatic decreases in viral load, current therapies do not provide a cure for HIV infection. We have used structure-based design and combinatorial medicinal chemistry to