Structure and Function of Ferritin

✍ Scribed by Dr. Robert R. Crichton

• Publisher: John Wiley and Sons
• Year: 1973
• Tongue: English
• Weight: 989 KB
• Volume: 12
• Category: Article
• ISSN: 0044-8249
• DOI: 10.1002/anie.197300571

✦ Synopsis

Abstract

Ferritin is the major iron storage protein of mammals and consists of up to 4500 atoms of ferric iron surrounded by a shell of protein subunits. The protein component, apoferritin, consists of 24 identical polypeptide chains each of molecular weight 18500. The function of ferritin is to store iron in a soluble form from which it can be readily mobilized. Recent results concerning the structure of the protein are reported, and progress in the elucidation of the mechanisms whereby iron is introduced into apoferritin and released from ferritin is reviewed.